Buspirone is primarily metabolized by which enzyme?

Buspirone is primarily metabolized by the enzyme CYP3A4, which is part of the cytochrome P450 family of enzymes located mainly in the liver. This enzyme plays a crucial role in the metabolism of a wide variety of substances, including many medications.

When buspirone is taken, CYP3A4 facilitates its conversion into its active metabolites, which are then further processed for elimination from the body. Understanding this metabolic pathway is important for predicting drug interactions, as substances that inhibit or induce CYP3A4 can significantly alter the levels and effectiveness of buspirone. This knowledge also underscores the significance of monitoring patients for interactions when they are prescribed multiple medications that may share the same metabolic pathway.

The choice of other enzyme options does not apply to buspirone's primary metabolism, as they are not primarily responsible for its breakdown in the body. Therefore, the correct identification of CYP3A4 as the main enzyme highlights the importance of considering enzyme-specific actions when prescribing and managing treatment with buspirone.