Trintellix is a substrate of which of the following enzymes?

Trintellix, also known as vortioxetine, is primarily metabolized in the liver, and its metabolic pathway involves specific cytochrome P450 enzymes. The correct choice indicates that Trintellix is a substrate of CYP2D6 and CYP3A4.

CYP2D6 is crucial for the metabolism of many psychotropic medications, and its activity can vary significantly among individuals due to genetic polymorphisms, impacting how Trintellix is processed in the body. CYP3A4 is another important enzyme involved in drug metabolism, affecting a wide range of medications. The involvement of both CYP2D6 and CYP3A4 suggests that when considering drug interactions or variations in drug efficacy and safety, these two enzymes are pivotal for Trintellix's pharmacokinetics.

The other options include combinations of enzymes that are not the primary pathways for Trintellix metabolism. Therefore, understanding the role of CYP2D6 and CYP3A4 specifically provides important insights into how Trintellix is metabolized and can inform clinical decisions related to potential drug interactions and individual patient responses.