Vortioxetine is a substrate of which two cytochrome P450 enzymes?

Vortioxetine is primarily metabolized by cytochrome P450 enzymes, specifically CYP2D6 and CYP3A4. These enzymes play crucial roles in the oxidative metabolism of various drugs, influencing their pharmacokinetics.

CYP2D6 is particularly important for the metabolism of many antidepressants and can significantly impact the drug's efficacy and safety based on individual genetic variations. Similarly, CYP3A4 is one of the most common enzymes involved in drug metabolism, handling a wide range of substances, including vortioxetine. Understanding the involvement of these specific enzymes is essential for predicting drug interactions and individual responses to treatment.

The knowledge of these particular enzymes is critical for practitioners in choosing the right medications and dosages, especially in populations with potential genetic polymorphisms affecting enzyme activity.