What class of medications do Venlafaxine and Duloxetine fall under?

Venlafaxine and Duloxetine are classified as SNRIs, or Serotonin-Norepinephrine Reuptake Inhibitors. This class of medications functions by inhibiting the reuptake of both serotonin and norepinephrine in the brain, which increases the levels of these neurotransmitters in the synaptic gap. This increase is important for improving mood and alleviating symptoms of depression and anxiety disorders.

SNRIs are typically used to treat major depressive disorder, generalized anxiety disorder, and certain chronic pain conditions. The dual action on serotonin and norepinephrine distinguishes them from SSRIs (Selective Serotonin Reuptake Inhibitors), which primarily focus on enhancing serotonin levels alone. This makes SNRIs an effective option for patients experiencing diverse symptoms related to mood disorders.

In contrast, tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) are older classes of antidepressants that have different mechanisms of action and side effect profiles, further reinforcing the correct classification of Venlafaxine and Duloxetine as SNRIs.