Which benzodiazepines have a medium half-life?

The correct answer identifies Lorazepam, Temazepam, and Estazolam as benzodiazepines with a medium half-life. Each of these medications falls within a half-life range that makes them effective for treating various anxiety and sleep-related disorders while differentiating them from short-acting and long-acting benzodiazepines.

Lorazepam, commonly used for anxiety and as a sedative, typically has a half-life of about 10 to 20 hours, positioning it among those with a medium half-life. Temazepam, primarily prescribed for insomnia, boasts a half-life of approximately 8 to 20 hours, also categorizing it as medium. Estazolam, used for sleep disorders, similarly has a half-life that spans roughly 10 to 24 hours, which again fits the medium classification.

Collectively, these medications provide a balance of efficacy and duration, making them suitable for conditions requiring moderate sedative effects without the prolonged action that characterizes long-acting benzodiazepines.

In contrast, some other medications listed, like Dalmane (Flurazepam), have a longer half-life, making them less representative of the medium category. Recognizing these pharmacokinetic profiles is crucial for ensuring appropriate prescribing