Which of the following is NOT a side effect associated with SSRIs?

Increased appetite is generally not recognized as a side effect associated with selective serotonin reuptake inhibitors (SSRIs). While SSRIs may sometimes lead to weight gain in the long term for some individuals, they are more commonly associated with weight loss or a neutral effect on appetite, especially in the initial stages of treatment.

In contrast, other options on the list are known side effects of SSRIs. For example, hypotension can occur due to various factors, including medication interactions or dehydration. Sexual dysfunction is a well-documented side effect encountered by many individuals taking SSRIs, often affecting libido and sexual performance. Gastrointestinal (GI) bleeding, while rarer, has been associated with SSRIs, particularly when combined with non-steroidal anti-inflammatory drugs (NSAIDs) or in patients with certain risk factors.

Therefore, the assertion that increased appetite is not a side effect of SSRIs aligns with clinical observations, making that choice the correct answer in the context of the question.