Which of the following is NOT a side effect of TCAs?

Tricyclic antidepressants (TCAs) are known to have various side effects due to their broad mechanism of action, which impacts several neurotransmitters and receptors in the brain and body. Weight gain, sedation, and orthostatic hypotension are indeed common side effects associated with this class of medications.

Weight gain often occurs as TCAs can increase appetite and alter metabolism. Sedation is a frequent effect due to the antihistaminic properties of many TCAs, making them more sedative than newer antidepressants. Orthostatic hypotension can result from the blockade of alpha-adrenergic receptors, leading to drops in blood pressure upon standing.

In contrast, weight loss is typically not associated with TCAs. While some individuals may experience weight loss due to factors like reduced appetite or increased activity levels stemming from improved mood, this is not a primary or common side effect of TCAs. Therefore, identifying weight loss as a side effect of TCAs is inaccurate, affirming that it is NOT a side effect of these medications. This reinforces the understanding that TCAs often lead to weight gain rather than weight loss.