Which of the following would decrease Lithium levels?

Increased sodium intake would decrease lithium levels because lithium and sodium share similar pathways for renal excretion. When sodium intake is high, the kidneys prioritize the excretion of sodium over lithium, which can lead to lower levels of lithium in the bloodstream. This is particularly relevant for patients on lithium therapy, as maintaining appropriate lithium levels is crucial for its therapeutic effectiveness and to avoid toxicity.

Increased sodium intake helps maintain a balanced electrolyte status, which is essential since fluctuations in sodium can result in corresponding changes in lithium levels. This interplay is vital for clinicians to understand when managing patients who are receiving lithium for conditions such as bipolar disorder.