Which side effect is associated with TCAs?

Tertiary amine tricyclic antidepressants (TCAs) are known for a range of side effects due to their anticholinergic properties and influence on multiple neurotransmitter systems. Among these side effects, tachycardia and arrhythmias are particularly significant. TCAs can block the reuptake of norepinephrine and serotonin, but they also have effects on the cardiovascular system, which may lead to an increase in heart rate (tachycardia) and potential arrhythmias. This occurs because TCAs can influence cardiac conduction pathways and alter autonomic nervous system responses.

In contrast, while hypertension can occur with some medications, it is not as directly associated with TCAs as tachycardia and arrhythmias are. Nausea and dizziness may be common side effects for various classes of antidepressants, including TCAs, but they are generally less serious and not as defining features of TCA side effects. The primary cardiovascular risks, particularly tachycardia and arrhythmias, are critical considerations for healthcare providers when prescribing and monitoring patients on TCAs.