Which side effect is particularly associated with Trazodone?

Priapism is a potential side effect that is particularly associated with Trazodone, making it a significant consideration when prescribing this medication. Trazodone is primarily an antidepressant that acts on the serotonin system, and although it is effective for treating depression and anxiety, its unique mechanism can occasionally lead to this rare but serious condition characterized by prolonged and often painful erections not related to sexual arousal. This side effect arises due to the drug's effect on alpha-adrenergic receptors and can require medical intervention if it occurs, emphasizing the importance of monitoring patients for this reaction.

While other side effects like weight gain, somnolence, and dizziness can occur with Trazodone, they are not as uniquely associated with it as priapism. Somnolence, for instance, is common with many antidepressants, particularly those with sedating properties, and dizziness can be a side effect of various medications due to their effects on blood pressure or as a residual side effect when starting or adjusting dosages. Weight gain is also seen with a range of psychiatric medications and is not specific to Trazodone. Thus, priapism stands out as a distinctive and noteworthy side effect linked directly to Trazodone, underscoring the